Large Blk

Large Blk

Studies Using Bcl-2 Antibodies

The Bcl-2 gene family is important in regulating apoptosis, i.e. programmed cell death. The use of Bcl antibodies forms an important part of disease research at the cellular level. Apoptosis is essential for efficient cellular function and is utilised in many areas; for example homeostasis, defence against pathogens and embryonic development.

Bcl-2 proteins control apoptosis mainly by regulating the permeability of the outer mitochondrial membrane. Mitochondrial function depends on a “switch-on/switch-off” mechanism; therefore both pro and antipoptotic Bcl-2 proteins are involved. Homeostasis is achieved by a balance of functions between these two groups.

There are a large number of Bcl-2 proteins, each with a target antibody which is used for detection and quantitative analysis during immunoassays. Bcl-2 covers 4 BH domains. These domains regulate and control protein function and heterodimerisation between different Bcl-2 members.

Antipoptotic Bcl-2 proteins promote survival of the cell. These include A1, Mcl-1, 2Bcl-2, Bcl-2, Bcl-XL and Bcl-W. These contain all 4 domains. The multidomain proapoptotic (antisurvival) group of  Bax, Bok and Bak contains BH domains 1, 2, and 3. The second proapoptotic group, BH3-only, comprises the Bad, Bid, Bik, Bim, Blk, Bmf, Bnip, Bcl-XS, Noxa, and Puma globulins. These have only the BH3 domain.

It is the ratio of pro to antisurvival Bcl-2 proteins which determine how susceptible cells are to apoptotic stimuli. Disruption of these levels, by increased or decreased expression of one or more proteins, is implicated in the development of various malignant tumours as well as non-malignant growths, AIDs, Downs Syndrome and diabetes.

Antipoptotic Bcl-2 is widely used in cancer research. Elevated levels are implicated in a number of tumours, and cause cellular resistance to proapoptotic proteins and chemotherapy treatments. On a more general scale, Bcl-2 proteins are useful biomarkers. Antibody suppliers like us at Novus Biologicals have a large range of marker protein antibodies on our databases.

About the Author

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which hoodie should i get for school?

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tyvm!!!

bouns:should i get these jeans?http://store.delias.com/item.do?itemID=46018&categoryID=421&page=1&color=VIT

should i get this tank?http://store.delias.com/content/browse/jsp/item-large-image.jsp?itemKey=152385&color=COR

should i get this tee?http://store.delias.com/content/browse/jsp/item-large-image.jsp?itemKey=152517&color=BLK
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all of the hoodies are ok except the first one!!!! that one is too much for me....&. i hope you have shirts or tank tops (aka undershirts) that are going to match those hoodies because zipping them all the way up is definetly not CUTE!! they aren't really my style sorry ; (

the jeans are ok there is nothing special about them they are just blue jeans

the tank top is cute

the tee is not something i would wear at all i don't know what to say about that...(i wouldn't get it)
well good luck

Jessica Chobot on Geraldo at Large